Homework Lance
New Intervention being evaluated to treat DM 2
GCU- Pathophysiology in Nursing Management of Client’s health
DM 2 Medication Management Intervention
Diabetes mellitus is a disease that is increasing throughout the nation. The prevalence’s of this disease is causing the health field to find all and any types of situations to this problem. Diabetes mellitus has several forms however the most common are types 1 and 2. Type 1 diabetes can happen as anyone age but normally occurs around age 30; the patient’s pancreas cannot produce insulin thus they have to inject themselves several times a day with insulin. Diabetes mellitus overall is defined as a disease where the pancreas isn’t able to produce the hormone insulin, which results in abnormal metabolism of carbohydrates. This problem then raises the levels of glucose in the blood and also in the urine, which makes the patient sick. Since this disease has become a chronic disease the medical professionals must find a solution. We may have an answer yet, thanks to Mr. Simpson’s article. In Simpson’s article Efficacy and Safety of oral Methazolamine in Patients with Type 2 diabetes, he seems very hopeful in that he may have found a real solution to type 2 diabetes (Simpson, 2014).
Simpson’s article explains the process of how he worked with a 24week placebo controlled double blind study to see the effects of an old drug, Methazolamide to help reduce type two diabetes (Simpson, 2014). In his study he used a total of 132 patients in which 76 patients were controlled. He had the remaining group, roughly 56 patients taking the placebo well he asked that the remaining controlled group take an oral methazolmide for 24 weeks (Simpson, 2014).All of his research was tested on mice before he used it on human patients. Also the drug question, Methazolamide has been approved by the FDA for help with another well-known disease, glaucoma. With the benefits of this drug, also come side effects such as some dose dependent and metabolic acidosis. All of this information was well received by Wacher’s as he continued on with his research.
Since the test was random his patients included men and women between the age of 18 and 75 years with type 2 diabetes. The test was meant for anyone who hasn’t been on medication for diabetes before, but who has taken metformin dose at least 2 months before the study began (Simpson, 2014). This process helped him going forward in his study, by allowing him to use a Gene Expression Signature screening to see the activity of the drug on diabetes. He clearly only used type 2 diabetes patients because type 2 diabetes is defined as a chronic metabolic disorder that is caused by high blood sugar and or insulin resistance, unlike type 1 where the patient completely needs insulin.
Simpson and his team had to check all aspects of their research, so while they were searching for a solution for type 2 diabetes they also checked the patients’ urine and liver to make sure they weren’t being further harmed in this study. Wacher and his team noticed throughout their research that there weren’t any alterations to glutamyltransferase and or other liver markers (Simpson, 2014). The research team did notice that the patients using the drug methazolamide were showing signs of reduced urinary micro albumin compared to the placebo group which showed no signs. Neither one of the groups had any creatine in their urea, and no abnormal renal function which is a problem that could happen while on this drug (Simpson, 2014).
The research team began noticing that the controlled group on the methazolmide drug started showing a rapid reduction in their alanine aminotransferase and a large increase in weight loss; however they weren’t able to produce insulin still (Simpson, 2014).This again is another component as to why this solution wouldn’t work for individuals who struggle with type 1 diabetes. The benefits of weight loss would be great for anyone suffering from diabetes; it’s another step in making the chronic disease no longer present. With all of these results gather, Simpson and his group were able to come to the conclusion that this drug would be a great archetype for an intervention in type 2 diabetes.
With the help of Simpson’s research, we were able to see how Methazolamide could positively impact the life of someone living with type 2 diabetes. It can help the individual with weight loss as well help them lower their high blood sugar and it works well in both genders. Unfortunately the research shown above is only geared towards one kind of diabetes, but we have to start somewhere to help the group diabetes issues. It may not be a cure but it’s surely one amazing start.
References:
Simpson, R. W., Nicholson, G. C., Proietto, J., Sarah, A., Sanders, K. M., Phillips, G., … & Krippner, G. (2014). Efficacy and safety of oral methazolamide in patients with type 2 diabetes: a 24-week, placebo-controlled, double-blind study. Diabetes care, 37(11), 3121-3123.
Diabetes Mellitus 2 Information from Wikipedia. Retrieved 6/24/17 1000: Retrieved from: https://en.wikipedia.org/wiki/Diabetes_mellitus_type_2
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