What childhood cancer may demonstrate patterns of inheritance that suggest a familial basis?

What childhood cancer may demonstrate patterns of inheritance that suggest a familial basis?

a.
Leukemia
b.
Retinoblastoma
c.
Rhabdomyosarcoma
d.
Osteogenic sarcoma

ANS: B

Retinoblastoma is an example of a pediatric cancer that demonstrates inheritance. The absence of the retinoblastoma gene allows for abnormal cell growth and the development of retinoblastoma. Chromosome abnormalities are present in many malignancies. They do not indicate a familial pattern of inheritance. The Philadelphia chromosome is observed in almost all individuals with chronic myelogenous leukemia. There is no evidence of a familial pattern of inheritance for rhabdomyosarcoma or osteogenic sarcoma cancers.